A-1165442
A-1165442 is a potent, competitive and orally available TRPV1 antagonist with an IC50 of 9 nM for human TRPV1.
Product Specifications
CAS Number
[1221443-94-2]
UNSPSC
12352005
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/A-1165442.html
Purity
99.92
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(NC1=CC=CC2=C1C=C(C)N=C2)N[C@H]3C4=CC=C(Cl)C=C4OC(CF)(CF)C3
Molecular Formula
C22H20ClF2N3O2
Molecular Weight
431.86
References & Citations
[1]Voight EA, et al. Discovery of (R) -1- (7-chloro-2,2-bis (fluoromethyl) chroman-4-yl) -3- (3-methylisoquinolin-5-yl) urea (A-1165442) : a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy. J Med Chem. 2014 Sep 11;57 (17) :7412-24.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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