Anti-CLAC-P Antibody

Rabbit Polyclonal Antibody specific to CLAC-P

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Alzheimer disease amyloid-associated protein, AMY, CLAC-P [Cleaved into: Collagen-like Alzheimer amyloid plaque component

Gene Name

COL25A1

NCBI Gene ID

UniProt

Q9BXS0

Cellular Locus

Membrane

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Synthetic peptide corresponding to aa 430-445 of the NC3 region of human and mouse CLAC-P.

Target Antigen

Collagen α-1(XXV) chain

Target

CLAC-P

Clonality

Polyclonal

Type

Antibody

Applications

WB, IHC

Field of Research

Neuroscience

Purification Method

Purified by immunoaffinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. {PubMed:15522881, PubMed:15615705, PubMed:15853808, PubMed:16300410}.

Additionnal Information

Immunoblotting: at 2-5ug/mL, a band of approx. 70 kDa is detected in HEK293 cell lysate <br><br>Immunohistochemistry (paraffin): at 5- 10ug/mL, positive staining of senile plaques in AD brains <br><br>These are recommended concen- trations. User should determine optimal concentrations for their applications.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Specificity

This antibody recognizes native and human and mouse CLAC-P.

Formulation

PBS, pH 7.4.

Buffer pH

pH 7.4

Target Background

Alzheimer's disease (AD) is characterized by deposition of beta-amyloid as senile plaques and cerebral amyloid angiopathy. The principal component of AD amyloid is the amyloid beta peptide (Abeta). Although production and deposition of Abeta appear closely related to the pathogenesis of AD, current evidence suggest that Abeta alone is not sufficient to cause neuronal death and symptoms of dementia. A component of senile plaque (SP), CLAC (collagen-like Alzheimer amyloid plaque component ) and its precursor CLAC-P are deposited with extracellular beta-amyloid and have been recently implicated in cell toxicity of beta- amyloid in AD brains. CLAC-P is a unique, membrane-bound collagen-like structure containing three Gly-X-Y repeat motifs and may define a novel class of neuronal collagens.