Human Citrullinated Histone H4

<strong>Human Citrullinated Histone H4</strong>_x000D_ <strong>Catalog number:</strong> B2016730_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 50 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 13.4 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80°C_x000D_ <strong>Keywords:</strong> Citrullinated Histone H4 (human, recombinant; His-tagged)_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Rada B. Neutrophil Extracellular Traps Methods Mol Biol. 2019;1982:517-528._x000D_ 2: Andrés M, García-Gomis D, Ponte I, Suau P, Roque A. Histone H1 Post-Translational Modifications: Update and Future Perspectives Int J Mol Sci. 2020 Aug 18;21(16):5941._x000D_ 3: Tessarz P, Kouzarides T. Histone core modifications regulating nucleosome structure and dynamics Nat Rev Mol Cell Biol. 2014 Nov;15(11):703-8._x000D_ 4: Tian Y, Li P, Wu Z, Deng Q, Pan B, Stringer KA, Alam HB, Standiford TJ, Li Y. Citrullinated Histone H3 Mediates Sepsis-Induced Lung Injury Through Activating Caspase-1 Dependent Inflammasome Pathway Front Immunol. 2021 Dec 7;12:761345._x000D_ 5: Zuo Y, Yalavarthi S, Shi H, Gockman K, Zuo M, Madison JA, Blair C, Weber A, Barnes BJ, Egeblad M, Woods RJ, Kanthi Y, Knight JS. Neutrophil extracellular traps in COVID-19 JCI Insight. 2020 Jun 4;5(11):e138999._x000D_ 6: Shi L, Aymonnier K, Wagner DD. Neutrophil stimulation with citrullinated histone H4 slows down calcium influx and reduces NET formation compared with native histone H4 PLoS One. 2021 May 17;16(5):e0251726._x000D_ 7: Masuda S, Nakazawa D, Shida H, Miyoshi A, Kusunoki Y, Tomaru U, Ishizu A. NETosis markers: Quest for specific, objective, and quantitative markers Clin Chim Acta. 2016 Aug 1;459:89-93._x000D_ 8: Wong SL, Demers M, Martinod K, Gallant M, Wang Y, Goldfine AB, Kahn CR, Wagner DD. Diabetes primes neutrophils to undergo NETosis, which impairs wound healing Nat Med. 2015 Jul;21(7):815-9._x000D_ 9: Perdomo J, Leung HHL, Ahmadi Z, Yan F, Chong JJH, Passam FH, Chong BH. Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia Nat Commun. 2019 Mar 21;10(1):1322._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/33773016">10: Liu X, Arfman T, Wichapong K, Reutelingsperger CPM, Voorberg J, Nicolaes GAF. PAD4 takes charge during neutrophil activation: Impact of PAD4 mediated NET formation on immune-mediated disease J Thromb Haemost. 2021 Jul;19(7):1607-1617. </a>_x000D_ _x000D_ <strong>Products Related to Human Citrullinated Histone H4 can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>