MTT5
MTT5 is a toll-like receptor 7 (TLR7) agonist. MTT5 can couple with Deruxtecan (HY-13631E) and exert anti-tumor activity in HER2 positive solid tumors through tumor cell killing and immune activation[1].
Product Specifications
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mtt5.html
Purity
98.49
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
COCCOC1=NC(N)=C2NC(N(C2=N1)CC3=CC=C(C=C3)C(N4CC5CNCC5C4)=O)=O
Molecular Formula
C22H27N7O4
Molecular Weight
453.49
References & Citations
[1]Yue H, et al. A DXd/TLR7-agonist dual-conjugate anti-HER2 ADC exerts robust anti-tumor activity through tumor cell killing and immune activation. Mol Cancer Ther. 2024 Jul 31.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR7
Available Sizes
Curated Selection
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