Purmorphamine (GMP)

Purmorphamine (GMP) is Purmorphamine (HY-15108) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Purmorphamine is a smoothened/Smo receptor agonist with an EC50 of 1 μM[1].

Product Specifications

CAS Number

[483367-10-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Smo

Type

GMP Small Molecules

Related Pathways

Stem Cell/Wnt

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/purmorphamine-gmp.html

Purity

99.90

Solubility

10 mM in DMSO

Smiles

N1(C2=CC=C(NC3=NC(OC4=CC=CC5=C4C=CC=C5)=NC6=C3N=CN6C7CCCCC7)C=C2)CCOCC1

Molecular Formula

C31H32N6O2

Molecular Weight

520.62

Precautions

H302, H315, H319, H335

References & Citations

[1]Karumbayaram S, et al. Directed differentiation of human-induced pluripotent stem cells generates active motor neurons. Stem Cells. 2009 Apr;27 (4) :806-11. |[2]Hu Y, et al. Directed differentiation of basal forebrain cholinergic neurons from human pluripotent stem cells. J Neurosci Methods. 2016 Jun 15;266:42-9. |[3]Hua T, et al. Phenotypic, metabolic, and biogenesis properties of human stem cell-derived cerebellar spheroids. Sci Rep. 2022 Jul 27;12 (1) :12880. |[4]Sharma R, et al. 3D Bioprinting Pluripotent Stem Cell Derived Neural Tissues Using a Novel Fibrin Bioink Containing Drug Releasing Microspheres. Front Bioeng Biotechnol. 2020 Feb 11;8:57. |[5]Sundberg M, et al. Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons. Stem Cells. 2013 Aug;31 (8) :1548-62.