Lodoxamide (tromethamine)

Lodoxamide tromethamine (U-42585E) is a medication for the treatment of prophylaxis of mast cell-mediated allergic disease.

Product Specifications

CAS Number

[63610-09-3]

Product Name Alternative

U-42585E

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Lodoxamide_tromethamine.html

Purity

99.83

Solubility

DMSO : 20 mg/mL (ultrasonic; warming) |H2O : ≥ 100 mg/mL

Smiles

N#CC1=CC(NC(C(O)=O)=O)=C(Cl)C(NC(C(O)=O)=O)=C1.OCC(CO)(N)CO.OCC(CO)(N)CO

Molecular Formula

C19H28ClN5O12

Molecular Weight

553.91

Precautions

H302, H315, H319, H335

References & Citations

[1]Watt GD, et al. Protective effect opf lodoxamide tromethamine on allergen inhalation challenge. J Allergy Clin Immunol. 1980 Oct;66 (4) :286-94.|[2]Barr ML, et al. Addition of a mast cell stabilizing compound to organ preservation solutions decreases lung reperfusion injury. J Thorac Cardiovasc Surg. 1998 Mar;115 (3) :631-6; discussion 636-7.|[3]Mann JS, et al. Inhaled lodoxamide tromethamine in the treatment of perennial asthma: a double-blind placebo-controlled study. J Allergy Clin Immunol. 1985 Jul;76 (1) :83-90.