Phen Green SK diacetate (5/6-mixture)

Phen green SK (PGSK) diacetate (PGSK diacetate (5/6-mixture) ) is a metal ion-sensitive fluorescent probe that can penetrate cell membranes. Phen green SK (PGSK) diacetate can react with a variety of metal ions, including Fe2+, Cd2+, Co2+, Ni2+, Zn2+, etc. Phen green SK (PGSK) diacetate chelates Fe2+, resulting in fluorescence quenching, which can be restored when a membrane-permeable chelator is added, thereby reflecting the changes in the intracellular chelatable iron pool. The excitation/emission maxima of Phen green SK diacetate are 507/532 nm, respectively[1][2][3].

Product Specifications

CAS Number

[234075-45-7]

Product Name Alternative

PGSK diacetate (5/6-mixture)

UNSPSC

12171500

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/phen-green-sk-diacetate.html

Purity

95.33

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C1=CC2=C(C3(C4=C(OC5=C3C=C(Cl)C(OC(C)=O)=C5)C=C(OC(C)=O)C(Cl)=C4)OC2=O)C=C1)NC6=C7C=CC=NC7=C8N=CC=CC8=C6.CC(OC(C(Cl)=C9)=CC%10=C9C%11(C%12=C(C(O%11)=O)C=CC(C(NC%13=C%14C=CC=NC%14=C%15N=CC=CC%15=C%13)=O)=C%12)C(C=C%16Cl)=C(O%10)C=C%16OC(C)=O)=O

Molecular Formula

C37H21Cl2N3O8

Molecular Weight

706.48

References & Citations

[1]Petrat F, et al. Determination of the chelatable iron pool of isolated rat hepatocytes by digital fluorescence microscopy using the fluorescent probe, phen green SK. Hepatology. 1999;29 (4) :1171-1179.|[2]Li L, et al. NDRG1 alleviates Erastin-induced ferroptosis of hepatocellular carcinoma. BMC Cancer. 2025 Mar 21;25 (1) :522.|[3]Xu Z, et al. Total extracts from Abelmoschus manihot (L.) alleviate radiation-induced cardiomyocyte ferroptosis via regulating redox imbalances mediated by the NOX4/xCT/GPX4 axis. J Ethnopharmacol. 2024 Nov 15;334:118582.