MMV688533

MMV688533 is an antimalarial agent with rapid anti-plasmodial activity and effective single-dose activity against Plasmodium falciparum infection in humanized mouse models. MMV688533 can inhibit the activity of asexual blood stage parasites with an IC50 value of 1.3 nM. MMV688533 exhibits excellent pharmacokinetic properties and safety[1].

Product Specifications

CAS Number

[2260904-47-8]

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/mmv688533.html

Purity

99.72

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(C#CC2=CC=C(C(F)(F)F)C(C(NC3=NC=CC=C3)=O)=C2)=CC(C(F)(F)F)=C1)NC(N)=N

Molecular Formula

C24H15F6N5O2

Molecular Weight

519.40

References & Citations

[1]Murithi J M, et al. The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance[J]. Science translational medicine, 2021, 13 (603) : eabg6013.