Ferroptosis inducer-3

Ferroptosis inducer-3 (compound JB3) is an oral bioactive inhibitor of RAF1, with the IC50 of 226.9 nM. Ferroptosis inducer-3 can induce ferroptosis and plays an important role in cancer research[1].

Product Specifications

UNSPSC

12352005

Target

Ferroptosis; Raf

Type

Reference compound

Related Pathways

Apoptosis; MAPK/ERK Pathway

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ferroptosis-inducer-3.html

Smiles

ClC1=CC=C(NC(NC2=CC=C(OC3=CC=C(Cl)C=C3OC)C=C2)=O)C=C1C(F)(F)F

Molecular Formula

C21H15Cl2F3N2O3

Molecular Weight

471.26

References & Citations

[1]Yun-Jeong Kim, et al. Remodeling of sorafenib as an orally bioavailable ferroptosis inducer for Lung Cancer by chemical modification of adenine-binding motif. Biomed Pharmacother. 2024 Jul:176:116758.