Ferroptosis inducer-3
Ferroptosis inducer-3 (compound JB3) is an oral bioactive inhibitor of RAF1, with the IC50 of 226.9 nM. Ferroptosis inducer-3 can induce ferroptosis and plays an important role in cancer research[1].
Product Specifications
UNSPSC
12352005
Target
Ferroptosis; Raf
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ferroptosis-inducer-3.html
Smiles
ClC1=CC=C(NC(NC2=CC=C(OC3=CC=C(Cl)C=C3OC)C=C2)=O)C=C1C(F)(F)F
Molecular Formula
C21H15Cl2F3N2O3
Molecular Weight
471.26
References & Citations
[1]Yun-Jeong Kim, et al. Remodeling of sorafenib as an orally bioavailable ferroptosis inducer for Lung Cancer by chemical modification of adenine-binding motif. Biomed Pharmacother. 2024 Jul:176:116758.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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