Mcl-1 inhibitor 10
Mcl-1 inhibitor 10 (compound 43) is a relatively strong MCL-1 inhibitor (IC50=0.67 μM) . Mcl-1 inhibitor 10 interacts with specific binding sites of MCL-1 protein to block the pro-survival signal of MCL-1 and push cancer cells into apoptosis. Mcl-1 inhibitor 10 can be used in the study of MCL-1 dependent cancers[1].
Product Specifications
CAS Number
1580484-33-8
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mcl-1-inhibitor-10.html
Smiles
O=C(C1=CC(C2=C(COC3=CC=CC(C(F)(F)F)=C3)C=CC=C2)=CC=C1O)O
Molecular Formula
C21H15F3O4
Molecular Weight
388.34
References & Citations
[1]Petros A M, et al. Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein[J]. Bioorganic & medicinal chemistry letters, 2014, 24 (6) : 1484-1488.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC400304-500 1x 500 µL
CD106 / VCAM1 (B-K9), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC740029-100 1x 100 µL
Fibronectin (TV-1), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC402899-100 1x 100 µL
Alkaline Phosphatase (Placental) / PLAP (Germ Cell Tumor Marker) (ALPP/2899R), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470827-100 1x 100 µL
Involucrin (IVRN/827), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details