TPA-NAC

TPA-NAC is a nonfluorogenic prodrug by introducing N-acetyl-L-cysteine (NAC) into a conjugated acceptor skeleton. TPA-NAC is capable of fluorogenic selective labeling of HSA[1].

Product Specifications

UNSPSC

12352005

Target

Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/tpa-nac.html

Solubility

10 mM in H2O

Smiles

OC([C@@H](NC(C)=O)CS/C(SC[C@@H](NC(C)=O)C(O)=O)=C1C(C2=CC(C3=CC=C(N(C4=CC=CC=C4)C5=CC=CC=C5)C=C3)=CC=C2C\1=O)=O)=O

Molecular Formula

C38H33N3O8S2

Molecular Weight

723.81

References & Citations

[1]Tianhong Wu, et al. A Rationally Designed Prodrug for the Fluorogenic Labeling of Albumin and Theranostic Effects on Drug-Induced Liver Injury. Anal Chem. 2024 Feb 16.