MTIC
MTIC, the active metabolite of Temozolomide (TMZ), is a DNA alkylating agent. MTIC has antitumor activity [1][2][3][4].
Product Specifications
CAS Number
3413-72-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mtic.html
Purity
99.51
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=C(/N=N/NC)N=CN1)N
Molecular Formula
C5H8N6O
Molecular Weight
168.16
Precautions
H302, H315, H319, H335
References & Citations
[1]Ramalho MJ, et al. Biophysical interaction of temozolomide and its active metabolite with biomembrane models: The relevance of drug-membrane interaction for Glioblastoma Multiforme therapy. Eur J Pharm Biopharm. 2019;136:156-163. |[2]Nagasawa HT, et al. The mechanism of alkylation of DNA by 5- (3-methyl-1-triazeno) imidazole-4-carboxamide (MIC), a metabolite of DIC (NSC-45388) . Non-involvement of diazomethane. Chem Biol Interact. 1974 Jun;8 (6) :403-13.|[3]Tsang LL, et al. Comparison of the cytotoxicity in vitro of temozolomide and dacarbazine, prodrugs of 3-methyl- (triazen-1-yl) imidazole-4-carboxamide. Cancer Chemother Pharmacol. 1991;27 (5) :342-6.|[4]Beal DD, et al. Carcinogenicity of the antineoplastic agent, 5- (3,3-dimethyl-1-triazeno) -imidazole-4-carboxamide, and its metabolites in rats. J Natl Cancer Inst. 1975 Apr;54 (4) :951-7.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
DLR-ACTH-g-48T 48 Tests
Goat Adrenocorticotropic Hormone (ACTH) ELISA Kit
Sign In for Pricing
View Details 
MBS1381810-01 0.02 mg (E-Coli)
Recombinant Staphylococcus haemolyticus Tyrosine--tRNA ligase (tyrS)
Sign In for Pricing
View Details MBS1381810-02 0.02 mg (Yeast)
Recombinant Staphylococcus haemolyticus Tyrosine--tRNA ligase (tyrS)
Sign In for Pricing
View Details