6-Azuridine

6-Azuridine (6-Azauridine) is an orally active purine nucleoside analogue. 6-Azuridine activates autophagic flux, induces Apoptosis that depends on AMPK and p53. 6-Azuridine exhibit both antitumor and antiviral activities[1][2][3][4][5][6].

Product Specifications

CAS Number

[54-25-1]

Product Name Alternative

6-Azauridine

UNSPSC

12352005

Hazard Statement

H302+H312+H332, H351

Target

AMPK; Apoptosis; Autophagy; MDM-2/p53; Nucleoside Antimetabolite/Analog; SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Others

Assay Protocol

https://www.medchemexpress.com/6-azuridine.html

Purity

99.83

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(N1)N([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)N=CC1=O

Molecular Formula

C8H11N3O6

Molecular Weight

245.19

Precautions

H302+H312+H332, H351

References & Citations

[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.|[2]Yallappa G N, et al. Design and synthesis of pyrazole derivatives for in vitro screening to protect angiotensin-converting enzyme 2 human cells against COVID-19. Current Medicine Research and Practice, 2021, 11 (5) : 206-210.|[3]Janeway CM, et al. Effects of 6-azauridine on nucleotides, orotic acid, and orotidine in L5178Y mouse lymphoma cells in vitro. Cancer Res. 1977 Dec;37 (12) :4382-8. |[4]Cha YE, et al. 6-Azauridine Induces Autophagy-Mediated Cell Death via a p53- and AMPK-Dependent Pathway. Int J Mol Sci. 2021 Mar 14;22 (6) :2947.|[5]Steffenhagen KA, et al. Evaluation of 6-azauridine and 5-iododeoxyuridine in the treatment of experimental viral infections. J Infect Dis. 1976 Jun;133 (6) :603-12.|[6]Conn HO, et al. Effect of 6-azauridine on plasma cell tumors of mice: correlation of antitumor effect with inhibition of orotic acid metabolism. Cancer Res. 1967 Apr;27 (4) :618-25.