Recombinant Mouse Interleukin-2/IL-2 Protein (active)
Product Specifications
Background
Interleukin-2 (IL-2) is an interleukin; a type of cytokine signaling molecule in the immune system; belongs to the IL-2 family. It is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells; NK cells; lymphokine-activated killer cells; monocytes; macrophages and oligodendrocytes.
Abbreviation
Interleukin-2/IL-2
Synonyms
Interleukin-2; IL-2; T-Cell Growth Factor; TCGF; Aldesleukin
UniProt
P04351
Accession Number
P04351
Expression System
HEK293 cells
Tag
C-His
Sequence
Ala21-Gln169
Field of Research
Immunology
Endotoxin
≤0.1 EU per μg by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Measured in a cell proliferation assay using HT-2 mouse T cells. The ED50 for this effect is 0.88-3.5 ng/mL, corresponding to a specific activity of 2.86x105-1.14x106 units/mg.
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
18.07 kDa
Observed Molecular Weight
22-25 kDa
Formulation
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
Species
Mouse
Available Sizes
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