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RET-IN-7

RET-IN-7 demonstrates potent in vitro RET kinase inhibition and robust in vivo efficacy in RET-driven tumor xenografts upon multiday dosing in mice.

Product Specifications

CAS Number

2763386-05-4

UNSPSC

12352005

Target

RET

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ret-in-7.html

Purity

98.00

Solubility

DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC12CCC(CC1)(CC2)N3C=C(C4=C3N=CN=C4N)C5=C(F)C=C(Cl)C(N)=C5)OC

Molecular Formula

C22H24ClFN6O2

Molecular Weight

458.92

References & Citations

[1]Mathison CJN, et al. Antitarget Selectivity and Tolerability of Novel Pyrrolo[2,3-d]pyrimidine RET Inhibitors. ACS Med Chem Lett. 2021 Nov 6;12 (12) :1912-1919.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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