GNE-502
GNE-502 is an orally active and potent degrader for estrogen receptor (ER) . GNE-502 can be used for the research of breast cancer[1].
Product Specifications
CAS Number
1953134-16-1
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gne-502.html
Concentration
10mM
Purity
99.73
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@H]1CC(C2=CC=CC=C2N3)=C3[C@@H](C4=CC=C(C=C4)OCCN5CC(C5)CF)N1S(=O)(C)=O
Molecular Formula
C25H30FN3O3S
Molecular Weight
471.59
References & Citations
[1]Zbieg JR, et al. Discovery of GNE-502 as an Orally Bioavailable and Potent Degrader for Estrogen Receptor Positive Breast Cancer [published online ahead of print, 2021 Aug 20]. Bioorg Med Chem Lett. 2021;128335.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
AZQ6NW63-Fluoro488 100 µg/Vial
Anti-Zebrafish GATA6 Antibody Fluoro488 Conjugated
Sign In for Pricing
View Details 
KN209707BN 1 Kit
Cytokeratin 19 (KRT19) Human Gene Knockout Kit (CRISPR)
Sign In for Pricing
View Details 
303479 100 µg
Neuropilin 1 (A5 Protein, BDCA4, Blood Dendritic Cell Antigen 4, CD 304, CD304, Neuropilin-1, Neuropilin1, Neuropilin1 Transmembrane Receptor, NP1, NPN1, NRP 1, NRP, NRP1, Vascular Endothelial Cell Growth Factor 165 Receptor, VEGF165R)
Sign In for Pricing
View Details 
MBS6490632-01 0.2 mL
NFE2L2, NT (NRF2, Nuclear Factor Erythroid 2-related Factor 2, NFE2-related Factor 2, NF-E2-related Factor 2, Nuclear Factor, Erythroid Derived 2, Like 2, HEBP1) (Azide free) (HRP)
Sign In for Pricing
View Details MBS6490632-02 5x 0.2 mL
NFE2L2, NT (NRF2, Nuclear Factor Erythroid 2-related Factor 2, NFE2-related Factor 2, NF-E2-related Factor 2, Nuclear Factor, Erythroid Derived 2, Like 2, HEBP1) (Azide free) (HRP)
Sign In for Pricing
View Details