GNE-502
GNE-502 is an orally active and potent degrader for estrogen receptor (ER) . GNE-502 can be used for the research of breast cancer[1].
Product Specifications
CAS Number
[1953134-16-1]
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gne-502.html
Concentration
10mM
Purity
99.73
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@H]1CC(C2=CC=CC=C2N3)=C3[C@@H](C4=CC=C(C=C4)OCCN5CC(C5)CF)N1S(=O)(C)=O
Molecular Formula
C25H30FN3O3S
Molecular Weight
471.59
References & Citations
[1]Zbieg JR, et al. Discovery of GNE-502 as an Orally Bioavailable and Potent Degrader for Estrogen Receptor Positive Breast Cancer [published online ahead of print, 2021 Aug 20]. Bioorg Med Chem Lett. 2021;128335.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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