PROTAC FLT-3 degrader 4
PROTAC FLT-3 degrader 4 is an orally active CRBN-based FLT3-PROTAC degrader that potently induces FLT3-ITD degradation through the ubiquitin-proteasome system. PROTAC FLT-3 degrader 4 shows highly selective to FLT3-ITD mutant acute myeloid leukemia (AML) cells. (Blue: CRBN ligand, Black: linker; Pink: FLT3 inhibitor) [1].
Product Specifications
CAS Number
2956722-48-6
UNSPSC
12352005
Target
Apoptosis; FLT3; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-flt-3-degrader-4.html
Solubility
10 mM in DMSO
Smiles
O=C1NC2=CC=C(C=C2/C1=C/C3=C(C(NC(CN4CCN(CC4)CC5CCN(CC5)C6=CC=C7C(N(C(C7=C6)=O)C8CCC(NC8=O)=O)=O)=O)=CN3)C)F
Molecular Formula
C39H41FN8O6
Molecular Weight
736.79
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Ep-CAM / CD326 (VU-1D9), CF555 conjugate, 0.1mg/mL
Pmel17 / gp100 / SILV (NKI-beteb), CF640R conjugate, 0.1mg/mL
Prolactin (Pituitary Tumor Marker) (PRL/2642), CF640R conjugate, 0.1mg/mL
HCG-intact (HCGab/52), CF405S conjugate, 0.1mg/mL
FOXA1 / HNF3A (FOXA1/2230R), CF647 conjugate, 0.1mg/mL
