PINT-87aa (TFA)
PINT-87aa TFA, an 87-amino acid (aa) peptide, is encoded by the circular form of the long intergenic non-protein-coding RNA p53-induced transcript (LINC-PINT) . PINT-87aa TFA directly interacts with polymerase associated factor complex (PAF1c) and inhibits the transcriptional elongation of multiple oncogenes. PINT-87aa TFA suppresses glioblastoma cell proliferation in vitro and in vivo[1].
Product Specifications
UNSPSC
12352209
Target
DNA/RNA Synthesis
Type
Peptides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pint-87aa-tfa.html
Purity
99.0
Solubility
H2O
Smiles
O=C(N[C@@H](CC(C)C)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC(C)C)C(N3[C@@H](CCC3)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CO)C(N[C@@H](CS)C(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N4[C@@H](CCC4)C(N[C@@H](CO)C(NCC(N[C@@H](CCSC)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](C)C(N5[C@@H](CCC5)C(NCC(NCC(N[C@@H](CC6=CNC7=CC=CC=C67)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC8=CC=C(C=C8)O)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CS)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CO)C(N[C@@H](CS)C(N[C@@H](CS)C(N[C@@H](CS)C(N[C@@H](CS)C(N[C@@H](CS)C(N[C@@H](CS)C(N[C@@H](CS)C(N[C@@H](CO)C(N[C@@H](CC9=CNC=N9)C(N[C@@H](C(C)C)C(NCC(N[C@@H](C)C(N%10[C@@H](CCC%10)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CC%11=CC=CC=C%11)C(N[C@@H](CC%12=CNC=N%12)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CC%13=CNC=N%13)C(N[C@@H](CC(O)=O)C(NCC(N[C@@H](CC%14=CNC=N%14)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCSC)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC%15=CNC=N%15)C(N[C@@H](CS)C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](C)C(N[C@@H](CC%16=CNC=N%16)C(NCC(N[C@@H](CC%17=CC=C(C=C%17)O)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCSC)N.OC(C(F)(F)F)=O
Molecular Formula
C396H628N140O115S13.C2HF3O2
Molecular Weight
9721.05
References & Citations
[1]Zhang M, et, al. A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma. Nat Commun. 2018 Oct 26;9 (1) :4475.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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