TI17
TI17 is an inhibitor of the thyroid hormone receptor-interacting protein Trip13 and has anticancer activity. TI17 effectively inhibits multiple myeloma (MM) cell proliferation and induces cell cycle arrest and apoptosis. Trip13 is an AAA-ATPase that mediates double-strand break (DSB) repair; TI17 inhibits Trip13 function and increases DNA damage[1].
Product Specifications
CAS Number
1005178-02-8
UNSPSC
12352005
Target
Apoptosis; Thyroid Hormone Receptor
Type
Reference compound
Related Pathways
Apoptosis; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ti17.html
Purity
97.0
Solubility
10 mM in DMSO
Smiles
OC(C1C2C=CC(C1C(NC3=CC=C(C=C3)CC4=CC=NC=C4)=O)C5CC25)=O
Molecular Formula
C23H22N2O3
Molecular Weight
374.44
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Dedicated for Diverse Library
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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