C108297

C108297 is a selective glucocorticoid receptor (GR) modulator (GR binding Ki 0.7 nM; GR reporter gene functional Ki 0.6 nM) . C108297 attenuates obesity by reducing caloric intake and increasing lipolysis and fat oxidation, and in addition attenuates inflammation[1][2].

Product Specifications

CAS Number

[864972-30-5]

UNSPSC

12352005

Target

Glucocorticoid Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/c108297.html

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COCCOC[C@]12CC3=C(C=C1CCN(C2)S(=O)(C4=CC=C(C=C4)C(C)(C)C)=O)N(N=C3)C5=CC=C(C=C5)F

Molecular Formula

C30H36FN3O4S

Molecular Weight

553.69

References & Citations

[1]Clark RD, et al. 1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as selective glucocorticoid receptor antagonists with high functional activity. Bioorg Med Chem Lett. 2008;18 (4) :1312-1317.|[2]van den Heuvel JK, et al. Identification of a selective glucocorticoid receptor modulator that prevents both diet-induced obesity and inflammation. Br J Pharmacol. 2016;173 (11) :1793-1804.