DMAT
Product Specifications
UNSPSC Description
DMAT is a potent and specific CK2 inhibitor with an IC50 value of 130 nM.
Target Antigen
Casein Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/DMAT.html
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CN(C)C1=NC2=C(Br)C(Br)=C(Br)C(Br)=C2N1
Molecular Weight
476.79
References & Citations
[1]Yde CW, et al. Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitorDMAT. Cancer Lett. 2007 Oct 28;256(2):229-37.|[2]Lawnicka H, et al. Anti-neoplastic effect of protein kinase CK2 inhibitor, 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole (DMAT), on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro. Cell Tissue Res. 2010 May;340(|[3]Pagano MA, et al. The selectivity of inhibitors of protein kinase CK2: an update. Biochem J. 2008 Nov 1;415(3):353-65.|[4]Sass G, et al. Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMAT. Int J Oncol. 2011 Aug;39(2):433-42.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15535/DMAT-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15535/DMAT-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
749234-11-5
Available Sizes
Curated Selection
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