DMAT
DMAT is a potent and specific CK2 inhibitor with an IC50 value of 130 nM.
Product Specifications
CAS Number
[749234-11-5]
Product Name Alternative
CK2 Inhibitor; Casein kinase II Inhibitor
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Casein Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/DMAT.html
Purity
98.41
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CN(C)C1=NC2=C(Br)C(Br)=C(Br)C(Br)=C2N1
Molecular Formula
C9H7Br4N3
Molecular Weight
476.79
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]Yde CW, et al. Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitorDMAT. Cancer Lett. 2007 Oct 28;256 (2) :229-37.|[2]Lawnicka H, et al. Anti-neoplastic effect of protein kinase CK2 inhibitor, 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole (DMAT), on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro. Cell Tissue Res. 2010 May;340 (|[3]Pagano MA, et al. The selectivity of inhibitors of protein kinase CK2: an update. Biochem J. 2008 Nov 1;415 (3) :353-65.|[4]Sass G, et al. Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMAT. Int J Oncol. 2011 Aug;39 (2) :433-42.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK2
Available Sizes
Curated Selection
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