DMAT

DMAT is a potent and specific CK2 inhibitor with an IC50 value of 130 nM.

Product Specifications

CAS Number

[749234-11-5]

Product Name Alternative

CK2 Inhibitor; Casein kinase II Inhibitor

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Casein Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/DMAT.html

Purity

98.41

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CN(C)C1=NC2=C(Br)C(Br)=C(Br)C(Br)=C2N1

Molecular Formula

C9H7Br4N3

Molecular Weight

476.79

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Yde CW, et al. Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitorDMAT. Cancer Lett. 2007 Oct 28;256 (2) :229-37.|[2]Lawnicka H, et al. Anti-neoplastic effect of protein kinase CK2 inhibitor, 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole (DMAT), on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro. Cell Tissue Res. 2010 May;340 (|[3]Pagano MA, et al. The selectivity of inhibitors of protein kinase CK2: an update. Biochem J. 2008 Nov 1;415 (3) :353-65.|[4]Sass G, et al. Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMAT. Int J Oncol. 2011 Aug;39 (2) :433-42.