SBP-7455
Product Specifications
UNSPSC Description
SBP-7455 is a potent, high affinity and orally active dual ULK1/ULK2 autophagy inhibitor with IC50s of 13 nM and 476 nM in the ADP-Glo assays, respectively. SBP-7455 potently inhibits ULK1/2 enzymatic activity and can be used for triple-negative breast cancer (TNBC) research[1].
Target Antigen
Autophagy; ULK
Type
Reference compound
Related Pathways
Autophagy
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sbp-7455.html
Smiles
FC(C1=CN=C(NC2=CC=C(OC)C(OC)=C2)N=C1NC3CC3)(F)F
Molecular Weight
354.33
References & Citations
[1]Huiyu Ren, et al. Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2020 Dec 10;63(23):14609-14625
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-137742/SBP-7455-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-137742/SBP-7455-SDS-MedChemExpress.pdf
CAS Number
1884222-74-5
Available Sizes
Curated Selection
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