SBP-7455
SBP-7455 is a potent, high affinity and orally active dual ULK1/ULK2 autophagy inhibitor with IC50s of 13 nM and 476 nM in the ADP-Glo assays, respectively. SBP-7455 potently inhibits ULK1/2 enzymatic activity and can be used for triple-negative breast cancer (TNBC) research[1].
Product Specifications
CAS Number
[1884222-74-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; ULK
Type
Reference compound
Related Pathways
Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sbp-7455.html
Concentration
10mM
Purity
98.01
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
FC(C1=CN=C(NC2=CC=C(OC)C(OC)=C2)N=C1NC3CC3)(F)F
Molecular Formula
C16H17F3N4O2
Molecular Weight
354.33
Precautions
H302, H315, H319, H335
References & Citations
[1]Huiyu Ren, et al. Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2020 Dec 10;63 (23) :14609-14625
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ULK1; ULK2
Available Sizes
Curated Selection
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