AC-178335
AC-178335 is a SRIF antagonist, with a Ki of 172 nM. AC-178335 blocks SRIF inhibition of adenylate cyclase in vitro (IC50=5.1 μM) . AC-178335 induces GH release in anesthetized rats[1].
Product Specifications
CAS Number
212966-15-9
UNSPSC
12352209
Target
Somatostatin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ac-178335.html
Smiles
CC(N[C@H](CC1=CN=CN1)C(N[C@H](CC2=CC=CC=C2)C(N[C@H]([C@H](C)CC)C(N[C@H](CCCNC(N)=N)C(N[C@@H](C(N[C@@H](C(N)=O)CC3=CC=CC=C3)=O)CC4=CNC5=CC=CC=C45)=O)=O)=O)=O)=O
Molecular Formula
C49H63N13O7
Molecular Weight
946.11
References & Citations
[1]Baumbach WR, et, al. A linear hexapeptide somatostatin antagonist blocks somatostatin activity in vitro and influences growth hormone release in rats. Mol Pharmacol. 1998 Nov;54 (5) :864-73.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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