Apraclonidine (hydrochloride)

Apraclonidine hydrochloride (ALO 2145), a selective α2 and weak α1 receptor agonist activity, effectively lowers intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution and has the ability to elevate the eye lid[1][2].

Product Specifications

CAS Number

[73218-79-8]

Product Name Alternative

ALO 2145

UNSPSC

12352005

Hazard Statement

H301+H311+H331

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/apraclonidine-hydrochloride.html

Purity

98.96

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : ≥ 12.5 mg/mL

Smiles

NC1=CC(Cl)=C(NC2=NCCN2)C(Cl)=C1.[H]Cl

Molecular Formula

C9H11Cl3N4

Molecular Weight

281.57

Precautions

H301+H311+H331

References & Citations

[1]Wijemanne S, et al. Apraclonidine in the treatment of ptosis. J Neurol Sci. 2017;376:129‐132.|[2]Searles RV, et al. Aqueous humor dynamics in anesthetized rats infused with intracameral apraclonidine. Pharmacology. 1999;58 (4) :220‐226.|[3]Yoriko Hayasaka, et al. Effects of topical antiglaucoma eye drops on prostaglandin E (2) -induced aqueous flare elevation in pigmented rabbits. Invest Ophthalmol Vis Sci