CYP1B1-IN-4
CYP1B1-IN-4 is a 2,4-diarylthiazole compound with selectively CYP1B1 inhibition (IC50=0.2 nM) . CYP1B1-IN-4 has little cytotoxicity and high stability in both human and rat liver microsomes[1].
Product Specifications
CAS Number
[2685779-55-7]
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cyp1b1-in-4.html
Purity
99.09
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
COC1=CC=C(C(OC)=C1)C2=NC(C3=CC=C(C=C3)C#N)=CS2
Molecular Formula
C18H14N2O2S
Molecular Weight
322.38
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Hachey AC, et al. Design of Cytochrome P450 1B1 Inhibitors via a Scaffold-Hopping Approach. J Med Chem. 2022 Dec 15.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP1
Available Sizes
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