KRASG12C IN-13
KRASG12C IN-13 (LY3499446) is a potent KRAS G12C inhibitor. KRASG12C IN-13 is promising for research of advanced solid tumors including non-small cell lung cancer and colorectal cancer[1].
Product Specifications
CAS Number
[2409131-50-4]
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/krasg12c-in-13.html
Purity
99.01
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(N1CCN(CC1)C2=NC=NC3=C(C(C4=C5N=C(N)SC5=C(F)C=C4)=C(C=C32)Cl)F)C=C
Molecular Formula
C22H17ClF2N6OS
Molecular Weight
486.92
References & Citations
[1]Nagasaka M, et al. KRAS G12C Game of Thrones, which direct KRAS inhibitor will claim the iron throne? Cancer Treat Rev. 2020 Mar;84:101974.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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