Z-Phe-Tyr (tBu) -diazomethylketone

Z-Phe-Tyr (tBu) -diazomethylketone is a potent cathepsin L inhibitor. Z-Phe-Tyr (tBu) -diazomethylketone mediates reovirus disassembly. Z-Phe-Tyr (tBu) -diazomethylketone decreases viral detection[1][2].

Product Specifications

CAS Number

[114014-15-2]

UNSPSC

12352005

Target

Cathepsin; SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/z-phe-tyr-tbu-diazomethylketone.html

Purity

99.0

Solubility

DMSO : ≥ 250 mg/mL

Smiles

O=C(N[C@H](C(C=[N+]=[N-])=O)CC(C=C1)=CC=C1OC(C)(C)C)[C@@H](NC(OCC2=CC=CC=C2)=O)CC3=CC=CC=C3

Molecular Formula

C31H34N4O5

Molecular Weight

542.63

References & Citations

[1]Ebert DH, et al. Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells. J Biol Chem. 2002 Jul 5;277 (27) :24609-17.|[2]Perez-Bermejo JA, et al. SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19. Sci Transl Med. 2021 Apr 21;13 (590) :eabf7872.