Phoenixin-14

Phoenixin-14 (PNX-14) is one of the endogenous active isoform, and generates anxiolytic effect via the activation of the AHA GnRH system in mice. Phoenixin-14 inhibits ischemia/reperfusion-induced cytotoxicity in microglia[1][2].

Product Specifications

CAS Number

[1415039-79-0]

Product Name Alternative

PNX-14

UNSPSC

12352209

Target

GnRH Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/phoenixin-14.html

Purity

99.16

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N1[C@@H](CCC1)C(N2[C@@H](CCC2)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N5[C@@H](CCC5)C(N[C@@H](CC6=CC=CC=C6)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N

Molecular Formula

C75H110N18O20

Molecular Weight

1583.78

References & Citations

[1]Jiang JH, et al. Effects of Phoenixin-14 on anxiolytic-like behavior in mice. Behav Brain Res. 2015;286:39-48.|[2]Ma H, et al. Phoenixin 14 inhibits ischemia/reperfusion-induced cytotoxicity in microglia. Arch Biochem Biophys. 2020;689:108411.