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RS 67333 (hydrochloride)

RS 67333 hydrochloride is a potent and selective 5-HT4 receptor (5-HT4R) partial agonist with a pKi of 8.7 in guinea-pig striatum. RS 67333 hydrochloride exhibits lower affinities at several other receptors including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1, D2 and muscarinic M1-M3 receptors. RS 67333 hydrochloride has neuroprotective effects, and can be used for Alzheimer's disease research[1].

Product Specifications

CAS Number

168986-60-5

UNSPSC

12352005

Hazard Statement

H302

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rs-67333-hydrochloride.html

Purity

99.68

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(Cl)=C(N)C=C1OC)CCC2CCN(CCCC)CC2.Cl

Molecular Formula

C19H30Cl2N2O2

Molecular Weight

389.36

Precautions

H302

References & Citations

[1]R M Eglen, et al. Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo. Br J Pharmacol. 1995 Aug;115 (8) :1387-92.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

5-HT1 Receptor;5-HT2 Receptor; Apolipoprotein D

Available Sizes

Frequently Asked Questions

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