THZ2
Product Specifications
UNSPSC Description
THZ2 is a potent and selective CDK7 inhibitor with an IC50 of 13.9 nM.
Target Antigen
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/THZ2.html
Purity
99.03
Solubility
DMSO : 21.67 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=CC(NC2=NC=C(Cl)C(C3=CNC4=C3C=CC=C4)=N2)=C1)C5=CC=CC(NC(/C=C/CN(C)C)=O)=C5
Molecular Weight
566.05
References & Citations
[1]Wang Y, et al. CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer. Cell. 2015 Sep 24;163(1):174-186.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12280/THZ2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12280/THZ2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1604810-84-5
Available Sizes
Curated Selection
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