EML 425
EML425 is a potent and selective CREB binding protein (CBP) /p300 inhibitor with IC50s of 2.9 and 1.1 μM, respectively.
Product Specifications
CAS Number
[1675821-32-5]
UNSPSC
12352005
Target
Epigenetic Reader Domain; Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Metabolic Disease; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/EML_425.html
Concentration
10mM
Purity
98.04
Solubility
DMSO : ≥ 250 mg/mL
Smiles
O=C(N(C(N(CC1=CC=CC=C1)C/2=O)=O)CC3=CC=CC=C3)C2=C/C4=C(C=C(O)C=C4C)C
Molecular Formula
C27H24N2O4
Molecular Weight
440.49
References & Citations
[1]Milite C, et al. A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach. J Med Chem. 2015 Mar 26;58 (6) :2779-98.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CBP/p300; TIP60
Available Sizes
Curated Selection
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