Agouti-related Protein (AGRP) (83-132) Amide (human)
Agouti-related Protein (AGRP) (83-132) Amide (human) is a fragment of agouti-related protein (AGRP) which is a protein found in abundance in the arcuate nucleus of the hypothalamus. AgRP primarily acts as an inverse agonist for the melanocortin-4 receptor (MC4R) to increase food intake[1][2].
Product Specifications
UNSPSC
12352209
Target
Melanocortin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/agouti-related-protein-agrp-83-132-amide-human.html
Solubility
H2O
Smiles
O=C([C@@H](N)CO)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H]2CSSC[C@H](NC3=O)C(NC(C(NC(C(NC(C(NCC(N[C@H](C(NC(C(NC(C(NC(C(N4C5CCC4)=O)CC(N)=O)=O)CCSC)=O)C)=O)[C@@H](C)O)=O)=O)CC(C)C)=O)CCCCN)=O)CCCNC(N)=N)=O)=O)CCC1)=O)C(C)C)=O)CCC(N)=O)=O)CCC(N)=O)=O)=O)CC(C)C)=O)CSSC[C@H](NC6=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]7CC8=CC=CC=C8)=O)C)=O)CC(N)=O)=O)CC9=CC=CC=C9)=O)CC%10=CC=CC=C%10)=O)CCCNC(N)=N)=O)CSSC[C@H](NC7=O)C(N[C@H]3CC%11=CC=C(O)C=C%11)=O)=O)CC%12=CC=C(O)C=C%12)=O)=O)CO)=O)CCC(O)=O)=O)CC%13=CNC=N%13)=O)CC(C)C)=O)CCCNC(N)=N)=O)C(C)C)=O)CSSC[C@H](NC2=O)C(N[C@H](C(N%14[C@H](C(N[C@H](C(N[C@H](C(N[C@H]6[C@@H](C)O)=O)C)=O)CSSCC(NC5=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)[C@@H](C)O)=O)CCCNC(N)=N)=O)CO)=O)=O)CCC%14)=O)CC(O)=O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CO
Molecular Formula
C235H362N76O67S11
Molecular Weight
5676.60
References & Citations
[1]Donald W. Pfaff, et al. Chapter 1 - Hormones Can Facilitate or Suppress Behaviors. Principles of Hormone/Behavior Relations (Second Edition) . Academic Press, 2018, Pages 3-26, ISBN 9780128113714.|[2]Tang-Christensen M, et al. Central administration of ghrelin and agouti-related protein (83-132) increases food intake and decreases spontaneous locomotor activity in rats. Endocrinology. 2004 Oct;145 (10) :4645-52.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
MC4R
Frequently Asked Questions
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