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Agouti-related Protein (AGRP) (83-132) Amide (human)

Agouti-related Protein (AGRP) (83-132) Amide (human) is a fragment of agouti-related protein (AGRP) which is a protein found in abundance in the arcuate nucleus of the hypothalamus. AgRP primarily acts as an inverse agonist for the melanocortin-4 receptor (MC4R) to increase food intake[1][2].

Product Specifications

UNSPSC

12352209

Target

Melanocortin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/agouti-related-protein-agrp-83-132-amide-human.html

Solubility

H2O

Smiles

O=C([C@@H](N)CO)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H]2CSSC[C@H](NC3=O)C(NC(C(NC(C(NC(C(NCC(N[C@H](C(NC(C(NC(C(NC(C(N4C5CCC4)=O)CC(N)=O)=O)CCSC)=O)C)=O)[C@@H](C)O)=O)=O)CC(C)C)=O)CCCCN)=O)CCCNC(N)=N)=O)=O)CCC1)=O)C(C)C)=O)CCC(N)=O)=O)CCC(N)=O)=O)=O)CC(C)C)=O)CSSC[C@H](NC6=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]7CC8=CC=CC=C8)=O)C)=O)CC(N)=O)=O)CC9=CC=CC=C9)=O)CC%10=CC=CC=C%10)=O)CCCNC(N)=N)=O)CSSC[C@H](NC7=O)C(N[C@H]3CC%11=CC=C(O)C=C%11)=O)=O)CC%12=CC=C(O)C=C%12)=O)=O)CO)=O)CCC(O)=O)=O)CC%13=CNC=N%13)=O)CC(C)C)=O)CCCNC(N)=N)=O)C(C)C)=O)CSSC[C@H](NC2=O)C(N[C@H](C(N%14[C@H](C(N[C@H](C(N[C@H](C(N[C@H]6[C@@H](C)O)=O)C)=O)CSSCC(NC5=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)[C@@H](C)O)=O)CCCNC(N)=N)=O)CO)=O)=O)CCC%14)=O)CC(O)=O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CO

Molecular Formula

C235H362N76O67S11

Molecular Weight

5676.60

References & Citations

[1]Donald W. Pfaff, et al. Chapter 1 - Hormones Can Facilitate or Suppress Behaviors. Principles of Hormone/Behavior Relations (Second Edition) . Academic Press, 2018, Pages 3-26, ISBN 9780128113714.|[2]Tang-Christensen M, et al. Central administration of ghrelin and agouti-related protein (83-132) increases food intake and decreases spontaneous locomotor activity in rats. Endocrinology. 2004 Oct;145 (10) :4645-52.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Isoform

MC4R

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