Corynoxine
Corynoxine, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria rhynchophylla. Corynoxine is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway[1].
Product Specifications
CAS Number
[6877-32-3]
UNSPSC
12352005
Hazard Statement
H300
Target
Autophagy
Type
Natural Products
Related Pathways
Autophagy
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Corynoxine.html
Purity
99.89
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(NC1=C2C=CC=C1)[C@@]32[C@@](C[C@H](/C(C(OC)=O)=C\OC)[C@H](CC)C4)([H])N4CC3
Molecular Formula
C22H28N2O4
Molecular Weight
384.47
Precautions
H300
References & Citations
[1]Chen LL, et al. Corynoxine, a natural autophagy enhancer, promotes the clearance of alpha-synuclein via Akt/mTOR pathway. J Neuroimmune Pharmacol. 2014 Jun;9 (3) :380-7.|[2]Sakakibara I, et, al. Effect of oxindole alkaloids from the hooks of Uncaria macrophylla on thiopental-induced hypnosis. Phytomedicine. 1998 Apr;5 (2) :83-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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