GSK-3β inhibitor 16
GSK-3β inhibitor 16 (compound 7c) is a GSK-3β inhibitor with the IC50 of 4.68 nM. GSK-3β inhibitor 16 decreases Tau hyperphosphorylated aggregate and alleviates cognitive impairments in the Scopolamin -induced model in mice[1].
Product Specifications
UNSPSC
12352005
Target
GSK-3; Tau Protein
Type
Reference compound
Related Pathways
Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gsk-3β-inhibitor-16.html
Smiles
COC1=CC(/C=N/NC(C2=CC=CC=C2N3)=CC3=O)=CC=C1OC
Molecular Formula
C18H17N3O3
Molecular Weight
323.35
References & Citations
[1]Abdo Moustafa E, et al. Discovery of novel quinolin-2-one derivatives as potential GSK-3β inhibitors for treatment of Alzheimer's disease: Pharmacophore-based design, preliminary SAR, in vitro and in vivo biological evaluation. Bioorg Chem. 2024;146:107324.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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