[D-Trp8]-γ-MSH (TFA)
[D-Trp8]-γ-MSH TFA is a potent and selective agonist of melanocortin 3 (MC3) receptor, with IC50s of 6.7 nM, 600 nM and 340 nM for hMC3, hMC4 and hMC5, respectively in CHO cells. [D-Trp8]-γ-MSH TFA could provide protection against multiple inflammatory disorders such as rheumatoid arthritis and colitis[1][2].
Product Specifications
UNSPSC
12352209
Target
Melanocortin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/d-trp8-γ-msh-tfa.html
Solubility
H2O
Smiles
OC(C(F)(F)F)=O.O=C(N[C@@H](C(C)C)C(N[C@@H](CCSC)C(NCC(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC5=CC=CC=C5)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC6=CC=C(C=C6)O)N
Molecular Formula
C74H99N21O16S.xC2HF3O2
Molecular Weight
1570.77 (free acid)
References & Citations
[1]Grieco P, et, al. D-Amino acid scan of gamma-melanocyte-stimulating hormone: importance of Trp (8) on human MC3 receptor selectivity. J Med Chem. 2000 Dec 28; 43 (26) : 4998-5002.|[2]Kadiri JJ, et, al. Melanocortin 3 receptor activation with [D-Trp8]-γ-MSH suppresses inflammation in apolipoprotein E deficient mice. Eur J Pharmacol. 2020 Aug 5; 880:173186.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
MC3R
Frequently Asked Questions
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