KKII5
KKII5 is a potent Lipoxygenase (LOX-1) inhibitor with an IC50 of 19 μM. KKII5 inhibits lipid peroxidation[1].
Product Specifications
CAS Number
[6381-55-1]
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Lipoxygenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/kkii5.html
Purity
98.60
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C1=CC=C(C=C1)C2C=C(NC(=S)N2)C3=CC=CC=C3
Molecular Formula
C16H14N2S
Molecular Weight
266.36
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
References & Citations
[1]Georgiou N, et al. Thiocarbohydrazone and Chalcone-Derived 3,4-Dihydropyrimidinethione as Lipid Peroxidation and Soybean Lipoxygenase Inhibitors. ACS Omega. 2023 Mar 21;8 (13) :11966-11977.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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