KKII5

KKII5 is a potent Lipoxygenase (LOX-1) inhibitor with an IC50 of 19 μM. KKII5 inhibits lipid peroxidation[1].

Product Specifications

CAS Number

[6381-55-1]

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Lipoxygenase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/kkii5.html

Purity

98.60

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C1=CC=C(C=C1)C2C=C(NC(=S)N2)C3=CC=CC=C3

Molecular Formula

C16H14N2S

Molecular Weight

266.36

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

References & Citations

[1]Georgiou N, et al. Thiocarbohydrazone and Chalcone-Derived 3,4-Dihydropyrimidinethione as Lipid Peroxidation and Soybean Lipoxygenase Inhibitors. ACS Omega. 2023 Mar 21;8 (13) :11966-11977.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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