Rufinamide-15N, d2-1
Rufinamide-15N, d2-1 (CGP 33101-15N, d2-1) is 15N- and deuterium-labeled Rufinamide.Rufinamide (CGP 33101) is an orally active antiepileptic compound that inhibits Na+ current activation, inhibits neuronal hyperexcitability, and has anticonvulsant effects. Rufinamide is used in the study of Lennox-Gastaut syndrome[1][2][3][4].
Product Specifications
CAS Number
2012598-91-1
Product Name Alternative
CGP 33101-15N, d2-1; E 2080-15N, d2-1; RUF 331-15N, d2-1
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Sodium Channel
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C(C1=C[15N](C([2H])([2H])C2=C(F)C=CC=C2F)N=N1)N
Molecular Formula
C10H6D2F2N3 15NO
Molecular Weight
241.20
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Chen JL, et.al. Inhibition of resurgent Na+ currents by rufinamide. Neuropharmacology. 2024 Apr 1;247:109835.|[3]White HS, et.al. The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models. Epilepsia. 2008 Jul;49 (7) :1213-20.|[4]Suter MR, et.al. Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state. Anesthesiology. 2013 Jan;118 (1) :160-72.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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