YHO-13177
YHO-13177, a acrylonitrile derivative, is an orally active, potent and specific inhibitor of breast cancer resistance protein (BCRP) and ABCG2 with an IC50 value of 10 nM. YHO-13177 potentiates the cytotoxicity of SN-38 in HCT116 and A549 cells that express BCRP. YHO-13177 combined with Irinotecan significantly suppresses the tumor growth in an HCT116/BCRP xenograft model[1][2][3].
Product Specifications
CAS Number
912287-56-0
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
BCRP
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/YHO-13177.html
Purity
99.65
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
N#C/C(C1=CC=C(OC)C(OC)=C1)=C\C2=CC=C(N3CCC(O)CC3)S2
Molecular Formula
C20H22N2O3S
Molecular Weight
370.47
Precautions
H302, H312, H332
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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