N-Ethyl-N-nitrosourea

N-Ethyl-N-nitrosourea (ENU) is a DNA alkylating agent. N-Ethyl-N-nitrosourea induces leukemia by alkylating nucleobases, disrupting DNA, and resulting in bone marrow suppression and the formation of leukemic cells. N-Ethyl-N-nitrosourea is teratogenic in vivo, inducing tumor formation and paw malformations in pregnant rats. N-Ethyl-N-nitrosourea cause central nervous system (CNS) tumors and genetic disorders[1][2].

Product Specifications

CAS Number

[759-73-9]

Product Name Alternative

ENU; N-Nitroso-N-ethylurea

UNSPSC

12352211

Hazard Statement

H301, H312+H332, H350, H360

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/n-ethyl-n-nitrosourea.html

Purity

99.92

Solubility

DMSO : 175 mg/mL (ultrasonic)

Smiles

O=NN(CC)C(N)=O

Molecular Formula

C3H7N3O2

Molecular Weight

117.11

Precautions

H301, H312+H332, H350, H360

References & Citations

[1]Hou X, et al. N-Ethyl-N-Nitrosourea Induced Leukaemia in a Mouse Model: Protective Effect of Icaritin via Inhibition of IL-6/JAK2/STAT3 Pathway Causes Apoptosis. J Inflamm Res. 2024 Feb 7;17:777-790.|[2]Goth R, et al. Persistence of O6-ethylguanine in rat-brain DNA: correlation with nervous system-specific carcinogenesis by ethylnitrosourea. Proc Natl Acad Sci U S A. 1974 Mar;71 (3) :639-43.