N-Ethyl-N-nitrosourea
N-Ethyl-N-nitrosourea (ENU) is a DNA alkylating agent. N-Ethyl-N-nitrosourea induces leukemia by alkylating nucleobases, disrupting DNA, and resulting in bone marrow suppression and the formation of leukemic cells. N-Ethyl-N-nitrosourea is teratogenic in vivo, inducing tumor formation and paw malformations in pregnant rats. N-Ethyl-N-nitrosourea cause central nervous system (CNS) tumors and genetic disorders[1][2].
Product Specifications
Product Name Alternative
ENU; N-Nitroso-N-ethylurea
UNSPSC
12352211
Hazard Statement
H301, H312+H332, H350, H360
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/n-ethyl-n-nitrosourea.html
Purity
99.92
Solubility
DMSO : 175 mg/mL (ultrasonic)
Smiles
O=NN(CC)C(N)=O
Molecular Formula
C3H7N3O2
Molecular Weight
117.11
Precautions
H301, H312+H332, H350, H360
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W019815/N-Ethyl-N-nitrosourea-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W019815/N-Ethyl-N-nitrosourea-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
No Development Reported
CAS Number
[759-73-9]
Available Sizes
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