SR18662

SR18662 is a potent inhibitor of Krüppel-like factor five (KLF5) with an IC50 of 4.4 nM and an analogue of ML264 (HY-19994) with improved inhibitory potency against colorectal cancer cells. SR18662 can be used for the study of colorectal cancer[1].

Product Specifications

CAS Number

[2505001-62-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

KLF

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sr18662.html

Purity

99.61

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

ClC1=CC(/C=C/C(NCC(N2CCN(CC2)S(C)(=O)=O)=O)=O)=CC=C1Cl

Molecular Formula

C16H19Cl2N3O4S

Molecular Weight

420.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Julie Kim, et al.The Novel Small-Molecule SR18662 Efficiently Inhibits the Growth of Colorectal Cancer In Vitroand In Vivo.Mol Cancer Ther.2019 Nov;18 (11) :1973-1984.