Tivozanib (hydrochloride hydrate)
Tivozanib hydrochloride hydrate is the hydrate hydrochloride form of Tivozanib. Tivozanib hydrochloride hydrate is a selective, orally active inhibitor for vascular endothelial growth factor receptor (VEGFR) -1, 2 3, with IC50s of 30, 6.5 and 15 nM, respectively. Tivozanib hydrochloride hydrate exhibits antitumor efficacy[1].
Product Specifications
CAS Number
682745-41-1
Product Name Alternative
AV-951 (hydrochloride hydrate) ; KRN951 (hydrochloride hydrate)
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tivozanib-hydrochloride-hydrate.html
Purity
99.83
Solubility
DMSO : 125 mg/mL (ultrasonic) |DMSO : 250 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=CC=C(C=C1Cl)OC2=CC=NC3=CC(OC)=C(C=C23)OC)NC4=NOC(C)=C4.Cl.O
Molecular Formula
C22H22Cl2N4O6
Molecular Weight
509.34
Precautions
H315, H319, H320
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
VEGFR1/Flt-1; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
HLA-Aw32 & HLA-A25 (MHC I) (CATA-1), CF647 conjugate, 0.1mg/mL
Cytokeratin 17 (E3), CF488A conjugate, 0.1mg/mL
Eosinophil Peroxidase (AHE-1), CF405S conjugate, 0.1mg/mL
CD50 (ICAM-3) (186-2G9), CF405S conjugate, 0.1mg/mL
