TCL1 (10-24)
TCL1 (10-24) is a encompassing the betaA strand of human TCL1. TCL1 (10-24) is a Akt inhibitor. TCL1 (10-24) interacts with the Akt PH domain prevented phosphoinositide binding and hence inhibits membrane translocation and activation of Akt. TCL1 (10-24) inhibits cellular proliferation and anti-apoptosis. TCL1 (10-24) has tumor growth in vivo[1].
Product Specifications
CAS Number
835655-37-3
UNSPSC
12352209
Target
Akt; Apoptosis
Type
Peptides
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tcl1-10-24.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC1=CNC=N1)C(N2[C@@H](CCC2)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](C)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC7=CC=CC=C7)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N
Molecular Formula
C88H123N23O23
Molecular Weight
1871.06
References & Citations
[1]Makoto Hiromura, et al. Inhibition of Akt kinase activity by a peptide spanning the betaA strand of the proto-oncogene TCL1. J Biol Chem. 2004 Dec 17;279 (51) :53407-18.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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