TOPOI/PARP-1-IN-2

TOPOI/PARP-1-IN-2 (compound 6c) is a dual PARP-1 and topoisomerase 1 (TOPO-1) inhibitor with IC50s of 32.2 nM and 46.2 nM, respectively. TOPOI/PARP-1-IN-2 shows a selectivity for PARP-1 over PARP-2. TOPOI/PARP-1-IN-2 disrupts the cell cycle at the S phase and induces apoptosis in NCI-60 cancer cell lines[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; PARP; Topoisomerase

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/topoi-parp-1-in-2.html

Smiles

S=C(N(NC(C1=C2C=CC=C1)=O)C2=O)N/N=C/C3=CC=CC=C3Cl

Molecular Formula

C16H11ClN4O2S

Molecular Weight

358.80

References & Citations

[1]Eman M Elkafoury, et al. Synergy trap for guardian angels of DNA: Unraveling the anticancer potential of phthalazinone-thiosemicarbazone hybrids through dual PARP-1 and TOPO-I inhibition. Bioorg Chem. 2024 Oct 29:153:107924.