TOPOI/PARP-1-IN-2
TOPOI/PARP-1-IN-2 (compound 6c) is a dual PARP-1 and topoisomerase 1 (TOPO-1) inhibitor with IC50s of 32.2 nM and 46.2 nM, respectively. TOPOI/PARP-1-IN-2 shows a selectivity for PARP-1 over PARP-2. TOPOI/PARP-1-IN-2 disrupts the cell cycle at the S phase and induces apoptosis in NCI-60 cancer cell lines[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; PARP; Topoisomerase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/topoi-parp-1-in-2.html
Smiles
S=C(N(NC(C1=C2C=CC=C1)=O)C2=O)N/N=C/C3=CC=CC=C3Cl
Molecular Formula
C16H11ClN4O2S
Molecular Weight
358.80
References & Citations
[1]Eman M Elkafoury, et al. Synergy trap for guardian angels of DNA: Unraveling the anticancer potential of phthalazinone-thiosemicarbazone hybrids through dual PARP-1 and TOPO-I inhibition. Bioorg Chem. 2024 Oct 29:153:107924.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1; PARP2; Topo I
Curated Selection
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