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AKR1C2/3-IN-1

AKR1C2/3-IN-1 (compound 3a) is a potent AKR1C2 and AKR1C3 inhibitor with IC50 values of 90, 50 nM, respectively. AKR1C2/3-IN-1 can be used as a radiation sensitizer and as a potentiator of chemotherapy cytotoxicity[1].

Product Specifications

CAS Number

3107747-45-2

UNSPSC

12352005

Target

Aldose Reductase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/akr1c2-3-in-1.html

Smiles

O=C(C(C1=O)=CC2=C(O1)C=C(O)C=C2)N(CC)CC

Molecular Formula

C14H15NO4

Molecular Weight

261.27

References & Citations

[1]Jonnalagadda S, et al. Coumarin-based Aldo-Keto Reductase Family 1C (AKR1C) 2 and 3 Inhibitors. ChemMedChem. 2024 Jul 8:e202400081.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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